Influence of tabletting machine speed on the characteristics of tablets prepared by direct compression agents having different particle size Tablet maki̇nesi̇ basim hizinin farkli parti̇kül büyüklüǧüne sahi̇p doǧrudan basim ajanlariyla hazirlanan tablet özelli̇kleri̇ne etki̇si̇

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Alǧin Yapar E., Baykara T.

Ankara Universitesi Eczacilik Fakultesi Dergisi, vol.37, no.1, pp.29-39, 2008 (Scopus) identifier

  • Publication Type: Article / Article
  • Volume: 37 Issue: 1
  • Publication Date: 2008
  • Doi Number: 10.1501/eczfak_0000000489
  • Journal Name: Ankara Universitesi Eczacilik Fakultesi Dergisi
  • Journal Indexes: Scopus
  • Page Numbers: pp.29-39
  • Keywords: Compression rate, Direct compression method, Particle size and distribution, Tablet characteristics, α-lactose
  • Ankara University Affiliated: Yes

Abstract

In this work, tablets were prepared by lactose based direct compression (DC) agents having varied particle size and distribution; Tablettose®70, Tablettose®80 and Tablettose®100 were evaluated by means of comparable statistics regarding two different speed (14 rpm, 28 rpm) of rotary machine reflecting 80% DC agent and 20% anhydrous lactose containing tablet characteristics; weight, thickness, hardness and disintegration time. It was determined that weights of tablets compressed with low speed were found in accordance with their tapped density and also variation between weight of tablets decreased by high speed compression. In the case of wide particle size distribution, high speed compression caused decrease in weight of tablets. It was observed that thickness, hardness and disintegration time of all tablets were increased/decreased in correlation with their variation in weight. Consequently it was determined that compression speed caused statistically significant difference between tablets on account of investigated tablet characteristics.