Akademik Veri Yönetim Sistemi
FLUORIDE, cilt.41, sa.1, ss.67-71, 2008 (SCI-Expanded)
Various effects of Panax ginseng (ginseng) on changes in haematological parameters induced by fluoride (F) in mice were studied. Sixty male adult Swiss albino mice were divided into six groups of ten mice in each group. F was supplied at a concentration of 40 mg F ion/L in the drinking water to group I without ginseng and to groups II and III along with ginseng at a level of 100 and 200 mg/kg bw/day, respectively. Groups IV and V were supplied with ginseng only, and group VI served as the control without IF or ginseng. Blood samples were taken on days 0, 15, and 30 from the hearts of the mice, and the counts of red blood cells (erythrocytes, RBC), white blood cells (leucocytes, WBC), neutrophils, and lymphocytes, and the levels of haemoglobin and haematocrit were determined. Although the lymphocyte count increased slightly, by the 30(th) day in the F group I a statistically significant decrease was observed in RBC, WBC, and neutrophil counts, as well as the haemoglobin and haematocrit values. On the other hand, in the IF plus ginseng groups II and III, a restorative increase comparable to levels in the control group was found by the 15(th) and 30(th) day in these parameters, respectively, in the RBC, WBC, neutrophil, and lymphocyte counts and the haemoglobin and haematocrit values. These results indicated that 40 mg F/L in the drinking water caused anemia in mice and that Panax gensing counteracted this effect.