Bicycloheptylamine-Doxorubicin Conjugate: Synthesis and Anticancer Activities in sigma(2) Receptor-Expressing Cell Lines

Alamri M. A., Ates-Alagoz Z., Adejare A.

MEDICINAL CHEMISTRY, cilt.16, sa.2, ss.192-201, 2020 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 16 Sayı: 2
  • Basım Tarihi: 2020
  • Doi Numarası: 10.2174/1573406415666190301145203
  • Dergi Adı: MEDICINAL CHEMISTRY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Agricultural & Environmental Science Database, Biotechnology Research Abstracts, EMBASE, MEDLINE
  • Sayfa Sayıları: ss.192-201
  • Anahtar Kelimeler: Sigma-2 receptor, anticancer, doxorubicin, drug delivery, bicycloheptylamine, cancer, DEATH, BINDING, SIRAMESINE, DELIVERY, LIGANDS, DRUGS
  • Ankara Üniversitesi Adresli: Evet

Özet

Background: Novel bicycloheptylamines were designed and synthesized. These compounds were found to be selective for sigma-2 receptors. These receptors have been found to be up to 10 fold over-expressed in certain cancer cell lines, leading to investigation of possible uses as a biomarker in diagnosis and/or treatment especially in cancers with poor prognosis.