Akademik Veri Yönetim Sistemi
5. Euroasia Biochemical Approaches and Technologies, Antalya, Türkiye, 2 - 05 Kasım 2023
Electro-spinning
is a process that enables the production of nanofibers, ranging in diameter
from nanometers to micrometers, offering precise control over fiber dimensions, by applying a high electric field to a polymer
solution.1 Wool
keratin is one of the most preferred environmentally available natural polymers
humans utilize as the shielding material for covering their body by imitating the warm
animal body.2 Due to
its versatile, attractive polypeptide chains, not only for apparel production,
it has also been employed as a substrate in different application fields
ranging from physicochemical industrial areas to biomedical purposes.
Poly(ethylene imine) (PEI), chosen as additives in the electro-spinning
technique, offer several advantages, including being highly effective in
antibacterial applications due to their polycationic nature while their low
cytotoxicity towards human cells, coupled with their ability to readily
traverse cell membranes and enhance membrane permeability, make them a
preferred choice for various biomedical applications. This work blended keratin
particles with gelatin and PEI polymers to obtain a nano-fiber web coating onto
the marbleshah woven cotton through an electro-spinning technique in different
morphologies, such as hybrid, Janus, and core-shell. To attain this objective,
we utilized a chemical reduction process on the waste wool material to improve
its permanent processability, such as ease of dissolution in different solvents
and forming interaction with the functional groups. Subsequently, after
identifying the appropriate solvent system for the keratin particles, we
prepared its solutions incorporating PEI and gelatin polymers, rendering them
suitable for the electrospinning process.
We extensively characterized the structural properties of the selected
polymers for blending, as well as the hydrophilicity and nanofibrous texture of
the fabric coatings, employing a comprehensive array of techniques, including
ATR-FTIR, optical microscopy, contact-angle measurements, and SEM. As a result,
this study revealed the fabrication of biocompatible composite material from
keratin-based nanofibrous coatings to be potentially used as a biomedical
substrate, such as filters, biocompatible meshes, and surgical reusable mask
material.