Allogeneic hematopoietic stem cell transplantation for refractory mycosis fungoides (MF) and Sezary syndrome (SS)

Atilla E., Atilla P. A., CİVRİZ BOZDAĞ S., YÜKSEL M., TOPRAK S. K., TOPÇUOĞLU P., ...Daha Fazla

INTERNATIONAL JOURNAL OF HEMATOLOGY, cilt.106, sa.3, ss.426-430, 2017 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 106 Sayı: 3
  • Basım Tarihi: 2017
  • Doi Numarası: 10.1007/s12185-017-2245-x
  • Dergi Adı: INTERNATIONAL JOURNAL OF HEMATOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.426-430
  • Anahtar Kelimeler: Mycosis fungoides, Sezary syndrome, Allogeneic hematopoietic stem cell transplantation, LYMPHOMA WORKING PARTY, CUTANEOUS-LYMPHOMAS, MARROW TRANSPLANTATION, INTERNATIONAL-SOCIETY, EUROPEAN-ORGANIZATION, TASK-FORCE, CLASSIFICATION, CANCER, BLOOD, EORTC
  • Ankara Üniversitesi Adresli: Evet

Özet

Cutaneous T cell lymphoma is a heterogeneous group of lymphoproliferative disorders with different clinical behavior and prognosis in which malignant T cells accumulate in the skin. In the relapsed/refractory stage, treatment strategy varies depending on clinical perspective. We retrospectively evaluated advanced stage relapse or refractory mycosis fungoides and Sezary syndrome patients who underwent allogeneic hematopoietic stem cell transplantation (allo-HSCT) at our hospital. The overall response rate was 25%, while the disease progressed and relapsed after transplant in 38% of patients. Allo-HSCT may be a reasonable treatment option in the relapsed/refractory stage.