Ultrastructural view of a promising anti TNF-alpha agent on hepatic ischaemia reperfusion injury

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Kilicoglu B., Kilicoglu S. S., Tuncal S., Onalan A. K., Celepli S., Tasova V., ...More

BRATISLAVA MEDICAL JOURNAL-BRATISLAVSKE LEKARSKE LISTY, vol.116, no.10, pp.601-607, 2015 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 116 Issue: 10
  • Publication Date: 2015
  • Doi Number: 10.4149/bll_2015_117
  • Journal Name: BRATISLAVA MEDICAL JOURNAL-BRATISLAVSKE LEKARSKE LISTY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.601-607
  • Keywords: liver, ischemia-reperfusion, liver injury, anti TNF-alpha, TUMOR-NECROSIS-FACTOR, HEME OXYGENASE-1, LIVER, ISCHEMIA/REPERFUSION, INDUCTION, TOLERANCE, CELLS, RATS
  • Ankara University Affiliated: Yes

Abstract

BACKGROUND: Ischemia reperfusion causes injury to the liver cells during transplantation, trauma and emergency surgery. We investigated whether the anti TNF-alpha agent, etanercept, can reduce injury in an animal model of ischemia reperfusion owing to the fact that TNF-alpha plays a critical role in the process of inflammation.