Tetrodotoxin-Sensitive Neuronal-Type Na+ Channels: A Novel and Druggable Target for Prevention of Atrial Fibrillation

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Munger M. A., OLĞAR Y., Koleske M. L., Struckman H. L., Mandrioli J., Lou Q., ...Daha Fazla

JOURNAL OF THE AMERICAN HEART ASSOCIATION, cilt.9, sa.11, 2020 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 9 Sayı: 11
  • Basım Tarihi: 2020
  • Doi Numarası: 10.1161/jaha.119.015119
  • Dergi Adı: JOURNAL OF THE AMERICAN HEART ASSOCIATION
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, CAB Abstracts, CINAHL, EMBASE, MEDLINE, Veterinary Science Database, Directory of Open Access Journals
  • Anahtar Kelimeler: atrial arrhythmias, atrial fibrillation, cardiac arrhythmias, neuronal-type Na+ channel blockade, POLYMORPHIC VENTRICULAR-TACHYCARDIA, LATE SODIUM CURRENT, DRUG-INDUCED MODEL, DEPENDENT BLOCK, ARRHYTHMIAS, RILUZOLE, RANOLAZINE, ARRHYTHMOGENESIS, CONTRACTILITY, SUPPRESSION
  • Ankara Üniversitesi Adresli: Evet

Özet

Background Atrial fibrillation (AF) is a comorbidity associated with heart failure and catecholaminergic polymorphic ventricular tachycardia. Despite the Ca2+-dependent nature of both of these pathologies, AF often responds to Na+ channel blockers. We investigated how targeting interdependent Na+/Ca2+ dysregulation might prevent focal activity and control AF.