Tetrodotoxin-Sensitive Neuronal-Type Na+ Channels: A Novel and Druggable Target for Prevention of Atrial Fibrillation
JOURNAL OF THE AMERICAN HEART ASSOCIATION, cilt.9, sa.11, 2020 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 9 Sayı: 11
- Basım Tarihi: 2020
- Doi Numarası: 10.1161/jaha.119.015119
- Dergi Adı: JOURNAL OF THE AMERICAN HEART ASSOCIATION
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, CAB Abstracts, CINAHL, EMBASE, MEDLINE, Veterinary Science Database, Directory of Open Access Journals
- Anahtar Kelimeler: atrial arrhythmias, atrial fibrillation, cardiac arrhythmias, neuronal-type Na+ channel blockade, POLYMORPHIC VENTRICULAR-TACHYCARDIA, LATE SODIUM CURRENT, DRUG-INDUCED MODEL, DEPENDENT BLOCK, ARRHYTHMIAS, RILUZOLE, RANOLAZINE, ARRHYTHMOGENESIS, CONTRACTILITY, SUPPRESSION
- Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
- Ankara Üniversitesi Adresli: Evet
Özet
Background Atrial fibrillation (AF) is a comorbidity associated with heart failure and catecholaminergic polymorphic ventricular tachycardia. Despite the Ca2+-dependent nature of both of these pathologies, AF often responds to Na+ channel blockers. We investigated how targeting interdependent Na+/Ca2+ dysregulation might prevent focal activity and control AF.