A possible relationship between Toxoplasma gondii and schizophrenia: A seroprevalence study
INTERNATIONAL JOURNAL OF PSYCHIATRY IN CLINICAL PRACTICE, cilt.13, sa.1, ss.82-87, 2009 (SCI-Expanded, SSCI, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 13 Sayı: 1
- Basım Tarihi: 2009
- Doi Numarası: 10.1080/13651500802624738
- Dergi Adı: INTERNATIONAL JOURNAL OF PSYCHIATRY IN CLINICAL PRACTICE
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Social Sciences Citation Index (SSCI), Scopus
- Sayfa Sayıları: ss.82-87
- Anahtar Kelimeler: Schizophrenia, Toxoplasma gondii, anti-Toxoplasma IgG, anti-Toxoplasma IgM, NECROSIS-FACTOR-ALPHA, ANTIBODIES, INFECTION, INDIVIDUALS, ASSOCIATION, EXPOSURE, AGENTS, CELLS
- Ankara Üniversitesi Adresli: Hayır
Özet
Objective. Schizophrenia is a pervasive neuropsychiatric disease of uncertain etiology. We aimed to investigate a possible association between Toxoplasma gondii infection and schizophrenia in this study. Method. We selected individuals with schizophrenia (n=88) and tested them with commercially available enzyme-linked immunosorbent assay (ELISA) for anti-Toxoplasma IgG and IgM antibodies and compared these seropositivity rate to those of controls without psychiatric disease (n=88). Results. The rate of IgG antibody in the schizophrenia patients (47.7%) was higher than the control groups (20.4%) (P0.001). We did not find any anti-Toxoplasma IgM seropositivity in both schizophrenia patients and control group. In schizophrenic patients with and without anti-Toxoplasma IgG groups statistical analysis did not reveal any correlation between demographic variables and Toxoplasma infection. Conclusion. Our findings supported previous studies indicate that T.gondii may play a role in etiopathogenesis in some cases of schizophrenia.