Interaction between hypertension and periodontitis

Ozmeric N., ELGÜN ÜLKAR S., Kalfaoglu D., Pervane B., Sungur C., Erguder I., ...Daha Fazla

ORAL DISEASES, cilt.30, sa.3, ss.1622-1631, 2024 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 30 Sayı: 3
  • Basım Tarihi: 2024
  • Doi Numarası: 10.1111/odi.14543
  • Dergi Adı: ORAL DISEASES
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, CAB Abstracts, CINAHL, MEDLINE, Veterinary Science Database
  • Sayfa Sayıları: ss.1622-1631
  • Anahtar Kelimeler: CRP, hypertension, IL-6, periodontitis, C-REACTIVE PROTEIN, CARDIOVASCULAR RISK-FACTORS, CORONARY-HEART-DISEASE, PERI-IMPLANT DISEASES, 2017 WORLD WORKSHOP, MYOCARDIAL-INFARCTION, CREVICULAR FLUID, CONSENSUS REPORT, BLOOD-PRESSURE, IL-6 LEVELS
  • Ankara Üniversitesi Adresli: Evet

Özet

Objective: The possible association between hypertension and periodontitis and the effect of hypertension on periodontal treatment were investigated by evaluating salivary and gingival crevicular fluid (GCF) interleukin (IL)-6 and C reactive protein (CRP) levels.Methods: Forty-two healthy individuals without any previously diagnosed systemic disease [10 periodontally healthy (control) and 10 periodontitis (CP)] and subjects with hypertension [13 periodontally healthy (HP) and 9 with periodontitis (CP + HP)] participated in the study. GCF and saliva samples were obtained at baseline and 4 weeks after Phase I periodontal treatment. Biochemical parameters were analyzed using ELISA.Results: Before the periodontal treatment, significantly higher GCF IL-6 and CRP levels were detected in CP + HP and CP groups compared to HP and control groups (p < 0.01). Salivary CRP level in CP + HP group was found to be higher than the control group (p < 0.05). Statistically significant gingival and plaque index measurements (p < 0.01) might suggest a possible effect of hypertension on periodontal status. Periodontal treatment significantly improved the clinical indices; however, biochemical parameters did not change after the treatment.Conclusion: The association of hypertension with periodontitis through local salivary and GCF inflammatory mediators might be possible in disease process.