Anodic voltammetry of cefotaxime

Yilmaz N., Biryol I.

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, vol.17, no.8, pp.1335-1344, 1998 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 17 Issue: 8
  • Publication Date: 1998
  • Doi Number: 10.1016/s0731-7085(98)00040-5
  • Journal Name: JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1335-1344
  • Keywords: cefotaxime, determination, voltammetry, glassy carbon electrode, GLASSY-CARBON ELECTRODE, ELECTROCHEMICAL REDUCTION, CEPHALOSPORINS, CEFTRIAXONE, CEFSULODIN, MEDIA
  • Ankara University Affiliated: No

Abstract

In this study electrooxidation of cefotaxime was investigated using specially activated glassy carbon (GC), platinum and carbon paste (CP) electrodes in different supporting electrolyte solutions and at different pHs. The data revealed that the shapes of the voltammograms and the numbers of the oxidation steps changed depending on the nature of the electrode. The nature of the supporting electrolyte was also important for the response of the electrode. From an analytical point of view, the activated GC electrode was the most favourable one. In 0.2 M H3PO4 with an activated GC electrode the calibration graph gave two lines with different slopes in the concentration ranges of 2 x 10(-5)-l x 10(-4) and 2 x 10(-4)-6 x 10(-4). The results of the recovery test and statistical analysis showed that the voltammetric method could be used for the determination of cefotaxime. (C) 1998 Elsevier Science B.V. All rights reserved.