Particle size design of digitoxin in supercritical fluids

ATİLA DİNÇER C., YILDIZ N., Calimli A.

JOURNAL OF SUPERCRITICAL FLUIDS, cilt.51, sa.3, ss.404-411, 2010 (SCI-Expanded, Scopus) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 51 Sayı: 3
  • Basım Tarihi: 2010
  • Doi Numarası: 10.1016/j.supflu.2009.10.006
  • Dergi Adı: JOURNAL OF SUPERCRITICAL FLUIDS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.404-411
  • Anahtar Kelimeler: Supercritical fluids, RESS, Particle size, Digitoxin, RSM, RAPID EXPANSION, SALICYLIC-ACID, MICRONIZATION, RESS, NANOPARTICLES, STABILIZATION, IBUPROFEN, CO2
  • Ankara Üniversitesi Adresli: Evet

Özet

Bioavailability of the pharmaceutical substances is very important for their activity. In case of necessity, bioavailability can be improved by reducing the particle size of the drugs. In this study, particle size of digitoxin was reduced by the Rapid Expansion of Supercritical Solutions (RESS). The effects of pre-expansion temperature (90-110 degrees C), flow rate (2.5-7.5 ml/min), spray distance (3-7 cm) on the size and size distribution of the precipitated digitoxin particles were carried out. The particles were characterized by dynamic light scattering (DLS), scanning electron microscopy (SEM), transmission electron microscopy (TEM) and LC-MS analysis.