Research Information System
Jinekoloji ve Obstetrik Dergisi, vol.17, no.4, pp.236-244, 2003 (Scopus)
Today, the most important risk factor for ovarian cancer is familial history. Nearly 10% of ovarian cancers and more than that of the early beginning ovarian cancers is related and associated with autosomal ovarian cancer hereditary genes. This poses that a major gene has responsible and has a 50% life-time penetrance in familial ovarian cancer cases. In multiple familial hereditary ovarian cancer syndrome patients with two or more affected generations, have significant risk for ovarian cancer. Hereditary ovarian cancer has three phenotypes as mammary-ovarian cancer syndrome, site-specific ovarian cancer and hereditary non-polyposis coli. Nowadays, the important progressions in genes which are related, also who have a tendency to mammary and ovarian cancer, and genetic consult diagnostic tests are remaining commonly used and taken place by media's support. The prevention and current management in hereditary gynecological cancers are still controversial. In this review, the current modality and follow-up protocols in hereditary ovarian and gynecologic cancers were studied.