Conduction velocity distribution: Early diagnostic tool for peripheral neuropathies

Kiziltan E., Dalkilic N., Guney F. B., Pehlivan F.

INTERNATIONAL JOURNAL OF NEUROSCIENCE, vol.117, no.2, pp.203-213, 2007 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 117 Issue: 2
  • Publication Date: 2007
  • Doi Number: 10.1080/00207450600582496
  • Journal Name: INTERNATIONAL JOURNAL OF NEUROSCIENCE
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.203-213
  • Keywords: compound action potential, conduction velocity distribution, demyelination, sciatic nerve, POTASSIUM CHANNELS, NERVE, SODIUM
  • Ankara University Affiliated: No

Abstract

In order to get early information on the functional state of smaller myelinated fibers this article investigated the applicability of conduction velocity distribution on compound action potential recorded in experimentally demyelinated frog sciatic nerve. Conduction velocity distribution histograms were estimated by using the mathematical model the authors enhanced. The results suggest that by using appropriate conduction velocity distribution model the diagnosis time in demyelinating neuropathy may be shortened at least three times as compared with conventional conduction velocity assessment. Therefore, it may be concluded that a well-defined model designed for the estimation of the conduction velocity distribution may be used as a diagnostic tool for the early phase of peripheral demyelinating neuropathies.