Determination of the structure of the energy landscape for coarse-grained off-lattice models of folding heteropolymers
PHYSICAL REVIEW E, cilt.78, sa.4, 2008 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 78 Sayı: 4
- Basım Tarihi: 2008
- Doi Numarası: 10.1103/physreve.78.041914
- Dergi Adı: PHYSICAL REVIEW E
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Ankara Üniversitesi Adresli: Evet
Özet
The structure of energy landscapes for a minimalist coarse-grained off-lattice protein model is presented to investigate the folding behaviors of heteropolymers. The obtained energy landscapes serve as a useful tool for visualization of the funnel-like structure of a considered system in the configuration space. Despite the simplicity of the model, the knowledge of the free-energy landscape enables us to show different folding characteristics known from real proteins and synthetic peptides, such as two-state folding and metastability.