Genotype A2/adw2 strain of hepatitis B virus in Turkey: A case report
Hepatitis Monthly, cilt.10, sa.4, ss.302-305, 2010 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 10 Sayı: 4
- Basım Tarihi: 2010
- Dergi Adı: Hepatitis Monthly
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.302-305
- Anahtar Kelimeler: Genotype, Hepatitis B virus
- Ankara Üniversitesi Adresli: Evet
Özet
Background and Aims: Previous studies have demonstrated the dominance of genotype D subtype ayw in patients with hepatitis B virus infection in Turkey. The aim of the present study is to report, for the first time, genotype A2 subtype adw2 of hepatitis B virus in a patient who is an inactive hepatitis B carrier in Turkey. Materials and Methods: Hepatitis B virus DNA isolated from the serum sample was amplified by polymerase chain reaction. The polymerase gene segment of the hepatitis B virus was directly sequenced. A distance matrix/UPGMA comparison was used for phylogenetic analysis, and the genotype of the virus was identified accordingly. The subgenotype and subtype of hepatitis B virus were also detected. Results: The genotyping of the patient revealed that the isolated hepatitis B virus was genotype A2/adw2. Discussion: The subtype is inconsistent with the previous data from Turkey; specifically, the identification of the A2/adw2 subtype of the hepatitis B virus in an inactive carrier is the first such case in Turkey. This finding suggests that the transmission of another genotype besides genotype D subtype ayw of the hepatitis B virus is possible in Turkey.