Benzamide and Benzamidine Compounds as New Inhibitors of Urokinase-type Plasminogen Activators

KUŞ C., Ozer E., Korkmaz Y., Yurtcu E., DAĞALP R.

MINI-REVIEWS IN MEDICINAL CHEMISTRY, vol.18, no.20, pp.1753-1758, 2018 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Review
  • Volume: 18 Issue: 20
  • Publication Date: 2018
  • Doi Number: 10.2174/1389557518666180816110740
  • Journal Name: MINI-REVIEWS IN MEDICINAL CHEMISTRY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1753-1758
  • Keywords: Imidazopyridine, benzamide, benzamidine, urinary plasminogen activator, uPAR, upamostat, POTENT ANTIMICROBIAL ACTIVITY, FADROZOLE HYDROCHLORIDE, DERIVATIVES, SYSTEM, INVASION, RECEPTOR
  • Ankara University Affiliated: Yes

Abstract

Background & Method: In this ongoing research, it is aimed to investigate the synthesis, structure identification and effects on urokinase-type plasminogen activators (uPA) and its receptor levels of 4-(3H-imidazo[4,5-b] pyridin-2-yl)-N-substituted benzamide and benzamidine derivatives. uPA levels obtained from 4b and 7d administration were similar to 5-FU (5-fluorouracil) for colorectal carcinoma cells (p<0.05). 4b and 7d significantly reduced uPAR (urokinase-type plasminogen activator receptor) levels on both cell lines (p<0.05).