Contribution to the alkaline degradation of cefepime
Microchemical Journal, cilt.76, sa.1-2, ss.61-63, 2004 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 76 Sayı: 1-2
- Basım Tarihi: 2004
- Doi Numarası: 10.1016/j.microc.2003.10.011
- Dergi Adı: Microchemical Journal
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.61-63
- Anahtar Kelimeler: antibiotic cefepime, alkaline degradation, UV-spectra, kinetics, voltammetric reductions
- Ankara Üniversitesi Adresli: Evet
Özet
Deviations of the value of the rate constant for borate anions of the first step in the degradation of the antibiotic cefepime from Bronsted relation and deviations from i=f(pH) plots in voltammetric reductions of the oximino group led to investigation of the kinetics of degradation of cefepime in ammonia, borate, CHES and glycine buffers pH 9.3 using UV-visible spectra. Presence of at least two consecutive processes was detected and an interaction of cefepime with glycine has been proved. Identification of intermediates is under investigation. © 2003 Elsevier B.V. All rights reserved.