Scavenging of superoxide anion radical and hydroxyl radical by novel thiazolyl-thiazolidine-2,4-dione compounds

BOZDAĞ DÜNDAR O., Gurkan S., Aboul-Enein H. Y., Kruk I., Kladna A.

LUMINESCENCE, cilt.24, sa.3, ss.194-201, 2009 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 24 Sayı: 3
  • Basım Tarihi: 2009
  • Doi Numarası: 10.1002/bio.1095
  • Dergi Adı: LUMINESCENCE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.194-201
  • Anahtar Kelimeler: thiazolyl-thiazolidine-2,4-dione compounds, superoxide radical, hydroxyl radical, chemiluminescene, electron paramagnetic resonance, ANTIDIABETIC ACTIVITY, DERIVATIVES, CANCER
  • Ankara Üniversitesi Adresli: Evet

Özet

The antioxidant behavior of a series of new synthesized substituted thiazolyl-thiazolidine-2,4-dione compounds (TZDs) was examined using chemiluminescence and electron paramagnetic resonance spin trapping techniques. 5,5-Dimethyl-1-pyrroline-N-oxide (DMPO) was used as the spin trap. The reactivity of TZDs with superoxide anion radical (O-2((center dot) over bar)) and hydroxyl radical (HO center dot) was evaluated using potassium superoxide/18-crown-6 ether dissolved in dimethylsulfoxide, and the Fenton-like reaction (Fe2+ + H2O2), respectively. The results showed that TZDs efficiently inhibited light emission from the O-2((center dot) over bar) generating system at a concentration of 0.05-1 mmol L-1 (5-94% reductions were found at 1 mmol L-1 concentration). The TZD compounds showed inhibition of HO2(center dot) over bar-dependent DMPO-OH spin adduct formation from DMPO (the amplitude decrease ranged from 8 to 82% at 1 mmol L-1 concentration). The findings showed that examined TZDs had effective activities as radical scavengers. Copyright (C) 2009 John Wiley & Sons, Ltd.