Evaluation of Potential Hepatotoxicity Induced by Bortezomib

MUTLUAY D., Abou Monsef Y., YÜCEL TENEKECİ G.

ACTA SCIENTIAE VETERINARIAE, cilt.49, 2021 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 49
  • Basım Tarihi: 2021
  • Doi Numarası: 10.22456/1679-9216.116456
  • Dergi Adı: ACTA SCIENTIAE VETERINARIAE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS, EMBASE, Food Science & Technology Abstracts
  • Anahtar Kelimeler: bortezomib, cancer, chemotherapy, hepatotoxicity, liver, proteasome inhibitor, PROTEASOME INHIBITORS, CHEMOTHERAPY, NEUROPATHY, STRATEGY, GROWTH
  • Ankara Üniversitesi Adresli: Evet

Özet

Background: Bortezomib, an inhibitor of 26S proteasome, is an anti-cancer therapeutic agent used in different cancer types. It leads to the arrest of the cancerous cell cycle by inhibiting angiogenesis and inducing apoptosis. Liver is the vital organ for detoxification and excretion of toxic products. The treatment with chemotherapy is a challenge, drugs are used to destroy cancer cells, but healthy cells can be affected during cancer treatment as well. The main objective of this study was to analyze the histopathological and biochemical effects of bortezomib on liver.