Akademik Veri Yönetim Sistemi
Ankara Universitesi Eczacilik Fakultesi Dergisi, cilt.40, sa.1, ss.54-73, 2016 (Scopus)
© 2016 University of Ankara. All rights reserved.Alzheimer disease is a progresive neurodegenerative disease which affects a lot of people worldwide and expected to affect more people in next years, characterized by memory and cognitive disfunctions. According to Alzheimer's Disease International (ADI) 2015 report almost 46 million people has affected from Alzheimer's disease or Alzheimer related diseases worldwide. The exact cause of the disease is stil unknown and radical therapy is not possible. Targeting to a specific organ is stil an unsolved problem for neurodegenerative disesases like Alzheimer's Disease because of the existance of blood brain barrier which is composed of tightly located endothelial cells and restricts the enterance on the unwanted substances to brain. Last developments in nanotechnology promise for solving this problem. It is expected from nanosized BBB drug delivery systems to develop drug delivery performance, improve the brain selectivity with targeting ligands, enhance blood brain barrier (BBB) permeability and decrease neurotoxicity. In this review Alzheimer's disease, obstacles for the treatment and the role of nanotechnology based drug delivery systems for overcoming this obstacles will be discussed.