Correlation between the functional impairment of bone marrow-derived circulating progenitor cells and the extend of coronary artery disease

Bozdag-Turan, Ilkay; Turan, R.; Paranskaya, Liliya; Arsoy, Nicole; Turan, C.; Akin, Ibrahim; Kische, Stephan; Ortak, Jasmin; Schneider, H.; Ludovicy, S.; Hermann, Tina; D'Ancona, Giuseppe; Durdu, Serkan; AKAR, AHMET; Ince, Hueseyin; Nienaber, Christoph

doi:10.1186/1479-5876-10-143

Correlation between the functional impairment of bone marrow-derived circulating progenitor cells and the extend of coronary artery disease

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Bozdag-Turan I., Turan R. G., Paranskaya L., Arsoy N. S., Turan C. H., Akin I., ...More

JOURNAL OF TRANSLATIONAL MEDICINE, vol.10, 2012 (SCI-Expanded)

Publication Type: Article / Article
Volume: 10
Publication Date: 2012
Doi Number: 10.1186/1479-5876-10-143
Journal Name: JOURNAL OF TRANSLATIONAL MEDICINE
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Keywords: Circulating progenitor cells, Migration capacity, Colony forming capacity, Ischemic heart disease, Diabetes, Coronary artery disease, CYTOKINE-INDUCED MOBILIZATION, ENDOTHELIAL-CELLS, MYOCARDIAL-ISCHEMIA, RISK-FACTORS, NUMBER, TRANSPLANTATION, STEM, REENDOTHELIALIZATION, EXPRESSION, ELEVATION
Ankara University Affiliated: Yes

Abstract

Background: Bone marrow-derived circulating progenitor cells (BM-CPCs) in patients with coronary heart disease are impaired with respect to number and functional activity. However, the relation between the functional activity of BM-CPCs and the number of diseased coronary arteries is yet not known. We analyzed the influence of the number of diseased coronary arteries on the functional activity of BM-CPCs in peripheral blood (PB) in patients with ischemic heart disease (IHD).