Relation between the insertion/deletion polymorphism of the angiotensin I converting enzyme gene and restenosis after coronary stenting

Gurlek A., GÜLEÇ H. S., KARABULUT H. G., Bokesoy I., TUTAR D. E., Pamir G., ...More

JOURNAL OF CARDIOVASCULAR RISK, vol.7, no.6, pp.403-407, 2000 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 7 Issue: 6
  • Publication Date: 2000
  • Doi Number: 10.1177/204748730000700602
  • Journal Name: JOURNAL OF CARDIOVASCULAR RISK
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED)
  • Page Numbers: pp.403-407
  • Keywords: angiotensin converting enzyme, restenosis, SMOOTH-MUSCLE CELLS, MAJOR RISK FACTOR, DELETION POLYMORPHISM, INTRAVASCULAR ULTRASOUND, ANGIOPLASTY, MECHANISMS
  • Ankara University Affiliated: Yes

Abstract

Background Observations with intravascular ultrasound demonstrated that neointimal hyperplasia is the predominant factor responsible for in-stent restenosis. Experimental data suggest that angiotensin I converting enzyme CAGE) plays a role in the thickening of neointima after balloon denudation. Insertion/deletion (I/D) polymorphism of the ACE gene is significantly associated with plasma level of ACE and subjects with D/D genotype have significantly higher plasma levels of ACE than normal.