Relation between the insertion/deletion polymorphism of the angiotensin I converting enzyme gene and restenosis after coronary stenting

Gurlek, A; GÜLEÇ, HASAN; KARABULUT, HALİL; Bokesoy, I; TUTAR, DURMUŞ; Pamir, G; Alpman, AHMET; Toydemir, R; Aras, O; Oral, D

doi:10.1177/204748730000700602

Relation between the insertion/deletion polymorphism of the angiotensin I converting enzyme gene and restenosis after coronary stenting

Gurlek A., GÜLEÇ H. S., KARABULUT H. G., Bokesoy I., TUTAR D. E., Pamir G., ...Daha Fazla

JOURNAL OF CARDIOVASCULAR RISK, cilt.7, sa.6, ss.403-407, 2000 (SCI-Expanded)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 7 Sayı: 6
Basım Tarihi: 2000
Doi Numarası: 10.1177/204748730000700602
Dergi Adı: JOURNAL OF CARDIOVASCULAR RISK
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED)
Sayfa Sayıları: ss.403-407
Anahtar Kelimeler: angiotensin converting enzyme, restenosis, SMOOTH-MUSCLE CELLS, MAJOR RISK FACTOR, DELETION POLYMORPHISM, INTRAVASCULAR ULTRASOUND, ANGIOPLASTY, MECHANISMS
Ankara Üniversitesi Adresli: Evet

Özet

Background Observations with intravascular ultrasound demonstrated that neointimal hyperplasia is the predominant factor responsible for in-stent restenosis. Experimental data suggest that angiotensin I converting enzyme CAGE) plays a role in the thickening of neointima after balloon denudation. Insertion/deletion (I/D) polymorphism of the ACE gene is significantly associated with plasma level of ACE and subjects with D/D genotype have significantly higher plasma levels of ACE than normal.