Relation between the insertion/deletion polymorphism of the angiotensin I converting enzyme gene and restenosis after coronary stenting

Gurlek A., GÜLEÇ H. S., KARABULUT H. G., Bokesoy I., TUTAR D. E., Pamir G., ...Daha Fazla

JOURNAL OF CARDIOVASCULAR RISK, cilt.7, sa.6, ss.403-407, 2000 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 7 Sayı: 6
  • Basım Tarihi: 2000
  • Doi Numarası: 10.1177/204748730000700602
  • Dergi Adı: JOURNAL OF CARDIOVASCULAR RISK
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED)
  • Sayfa Sayıları: ss.403-407
  • Anahtar Kelimeler: angiotensin converting enzyme, restenosis, SMOOTH-MUSCLE CELLS, MAJOR RISK FACTOR, DELETION POLYMORPHISM, INTRAVASCULAR ULTRASOUND, ANGIOPLASTY, MECHANISMS
  • Ankara Üniversitesi Adresli: Evet

Özet

Background Observations with intravascular ultrasound demonstrated that neointimal hyperplasia is the predominant factor responsible for in-stent restenosis. Experimental data suggest that angiotensin I converting enzyme CAGE) plays a role in the thickening of neointima after balloon denudation. Insertion/deletion (I/D) polymorphism of the ACE gene is significantly associated with plasma level of ACE and subjects with D/D genotype have significantly higher plasma levels of ACE than normal.