Polymorphisms and Protein Expressions of Glutathione S-Transferase M1 and T1 in Non-Small Cell Lung Cancer

KILIÇ M., ADA A. O., OĞUZTÜZÜN S., Demirag F., ÇELİK S., Bicakcioglu P., ...Daha Fazla

TURKISH JOURNAL OF PHARMACEUTICAL SCIENCES, cilt.14, sa.3, ss.237-242, 2017 (ESCI) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 14 Sayı: 3
  • Basım Tarihi: 2017
  • Doi Numarası: 10.4274/tjps.74745
  • Dergi Adı: TURKISH JOURNAL OF PHARMACEUTICAL SCIENCES
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.237-242
  • Anahtar Kelimeler: GSTM1, GSTT1, polymorphism, protein expression, non-small cell lung carcinoma, GSTP1 POLYMORPHISMS, TURKISH POPULATION, RISK, GENOTYPE, GSTM1, GSTT1, CYTOCHROME-P450, ASSOCIATION, METABOLISM, TUMOR
  • Ankara Üniversitesi Adresli: Evet

Özet

Objectives: The deletion polymorphisms of glutathione S-transferase (GST) GSTM1 and GSTT1 genes result in the absence of the corresponding protein, which decreases the detoxification of carcinogens. Studies evaluating polymorphisms and protein expressions in the same patients are limited. Therefore, in this study, we aimed to investigate the association between polymorphisms and protein expressions of GSTM1 and GSTT1 in lung tissues of patients with non-small cell lung cancer (NSCLC).