Vitamin D levels in patients with small and medium vessel vasculitis

KORKMAZ F. N., Ozen G., Unal A. U., Odabasi A., Can M., AŞICIOĞLU E., ...More

REUMATOLOGIA CLINICA, vol.18, no.3, pp.141-146, 2022 (ESCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 18 Issue: 3
  • Publication Date: 2022
  • Doi Number: 10.1016/j.reuma.2020.11.004
  • Journal Name: REUMATOLOGIA CLINICA
  • Journal Indexes: Emerging Sources Citation Index (ESCI), Scopus, Academic Search Premier, EMBASE, MEDLINE, DIALNET
  • Page Numbers: pp.141-146
  • Keywords: Vasculitis, Vitamin D, Deficiency, Rheumatoid arthritis, RHEUMATOID-ARTHRITIS, DISEASE-ACTIVITY, 25-HYDROXYVITAMIN D, D DEFICIENCY, GENE POLYMORPHISMS, IMMUNE-RESPONSE, ASSOCIATIONS
  • Ankara University Affiliated: Yes

Abstract

Objectives: To determine the prevalence of vitamin D deficiency in patients with small and medium vessel systemic vasculitis. Methods: In this cross-sectional study, 25-hydroxy (OH) vitamin D3 levels were measured in adult patients with systemic small and medium vessel vasculitis including antineutrophil cytoplasmic antibody-associated vasculitis (AAV), cryoglobulinaemic vasculitis (CryV), IgA vasculitis (IgAV) and pol-yarteritis nodosa (PAN), and age- and sex-matched healthy subjects (HS) and patients with rheumatoid arthritis (RA) as control groups. 25OH vitamin D3 levels < 30 ng/ml and < 20 ng/ml were regarded as insufficiency and deficiency, respectively. Results: Fifty-seven patients (42 AAV, 2 CryV, 8 IgA vasculitis, 5 PAN) with systemic vasculitis, 101 HS, and 111 RA patients were included. The mean 25OH vitamin D3 level was 21.8 +/- 14.2 ng/mL in patients with vasculitis, 42.7 +/- 27.6 ng/mL in HS (p < .001) and 20.1 +/- 18.47 ng/mL in patients with RA (p = .54). Vitamin D insufficiency and deficiency were significantly higher in patients with systemic vasculitis compared to HS (75.4% vs 33.7%, p < .001; %50 vs 21.8%, p < .001, respectively). Vitamin D status was not different in patients with systemic vasculitis compared to RA. There was a negative correlation between vitamin D status and CRP levels (=-.364, p = .007). The multivariate logistic regression analysis showed that renal involvement was significantly associated with vitamin D deficiency/insufficiency in patients with vasculitis (OR 22.5 [95% CI 1.6-128.9]. Conclusion: Vitamin D deficiency and insufficiency are more frequent in patients with systemic small and medium vessel vasculitis and RA than HS. Renal involvement is one of the factors associated with vitamin D deficiency/insufficiency in patients with vasculitis. (c) 2020 Elsevier Espa na, S.L.U. and Sociedad Espa nola de Reumatologia y Colegio Mexicano de Reumatologia. All rights reserved.