A Cyclin D1 (CCND1) Gene Polymorphism Contributes to Susceptibility to Papillary Thyroid Cancer in the Turkish Population

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Aytekin T., Aytekin A., MARALCAN G., Gokalp M. A., ÖZEN D., Borazan E., ...Daha Fazla

ASIAN PACIFIC JOURNAL OF CANCER PREVENTION, cilt.15, sa.17, ss.7181-7185, 2014 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 15 Sayı: 17
  • Basım Tarihi: 2014
  • Doi Numarası: 10.7314/apjcp.2014.15.17.7181
  • Dergi Adı: ASIAN PACIFIC JOURNAL OF CANCER PREVENTION
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.7181-7185
  • Anahtar Kelimeler: Papillary thyroid cancer, cyclin D1 gene, polymorphism, Turkish population, SQUAMOUS-CELL CARCINOMA, INCREASED RISK, G870A POLYMORPHISM, COLORECTAL-CANCER, A870G POLYMORPHISM, LUNG-CANCER, AA GENOTYPE, ASSOCIATION, INHIBITORS, PROGNOSIS
  • Ankara Üniversitesi Adresli: Evet

Özet

Cyclin D1 is an important positive regulator of the G1/S phase of the cell cycle. We investigated the association between the CCND1 G870A polymorphism and susceptibility to papillary thyroid cancer in Turkish people. This study covered 102 patients with papillary thyroid cancer and 174 healthy controls. CCND1 genotyping was determined by the PCR-RFLP method. We found that the A allele frequency was higher in the cases than in the controls (p=0.042). On stratification analysis, papillary thyroid cancer risk was significantly elevated in individuals older than 45 years with the A allele (OR=1.91, 95% CI, 1.09-3.35, p=0.024) and in females with the A allele (OR=1.73, 95% CI, 1.06-2.84, p=0.029), compared to the G allele. According to the subject age, there was an increased papillary thyroid cancer risk for the individuals older than 45 years with the AA genotype (OR=2.28, 95% CI, 1.02-5.13, p=0.046) compared to the AG+GG combined genotypes. In conclusion, it is suggested that the CCND1 G870A polymorphism may contribute to the susceptibility to papillary thyroid cancer, especially in those who were older subjects (45 <= years old) and female, in the Turkish population.