Pharmacogenomic Markers of Targeted Therapy Toxicity in Patients with Metastatic Renal Cell Carcinoma

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de Velasco G., Gray K. P., Hamieh L., ÜRÜN Y., Carol H. A., Fay A. P., ...Daha Fazla

EUROPEAN UROLOGY FOCUS, cilt.2, sa.6, ss.633-639, 2016 (SCI-Expanded, Scopus) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 2 Sayı: 6
  • Basım Tarihi: 2016
  • Doi Numarası: 10.1016/j.euf.2016.03.017
  • Dergi Adı: EUROPEAN UROLOGY FOCUS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.633-639
  • Anahtar Kelimeler: Biomarker, Genomics, Polymorphisms, Renal cell carcinoma, Single-nucleotide polymorphism, Targeted therapy
  • Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
  • Ankara Üniversitesi Adresli: Evet

Özet

Background: Targeted therapy (TT) in metastatic renal cell carcinoma (mRCC) may be associated with a high rate of toxicity that undermines treatment efficacy and patient quality of life. Polymorphisms in genes involved in the pharmacokinetic pathways of TTs may predict toxicity.