Uveitis model in rabbit: Dexamethasone loaded PHBSA nanoparticles

Erdal E., Batur B., Uğurlu N., Çetin E. A., Türkoğlu N. L., Çakal C., ...Daha Fazla

Experimental Eye Research, cilt.266, 2026 (SCI-Expanded, Scopus) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 266
  • Basım Tarihi: 2026
  • Doi Numarası: 10.1016/j.exer.2026.110930
  • Dergi Adı: Experimental Eye Research
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, BIOSIS, Chemical Abstracts Core, EMBASE
  • Anahtar Kelimeler: Dexamethasone, PHBSA nanoparticles, Reduce injection frequency, Uveitis
  • Ankara Üniversitesi Adresli: Evet

Özet

The study aims to investigate the efficacy and safety of intravitreal dexamethasone-loaded polyhydroxybutyrate-stearic acid blend nanoparticles (PHBSA) in treating experimental uveitis. Dexamethasone (DEX) loaded PHBSA nanoparticles were fabricated. An experimental autoimmune uveitis model was established in rabbits and administered the nanoparticles. Fundus fluorescence photometry (FFM), optical coherence tomography (OCT), and fundus examinations were conducted to assess the treatment's effectiveness. Additionally, cytokine levels in the anterior chamber were measured. The uveitis rabbit model was successfully created by the intravitreal injection of 2 μg of lipopolysaccharides (LPS). Following the administration of the DEX-loaded PHBSA nanoparticles, clinical evaluations revealed significant therapeutic effects in both OCT and FFM measurements. A noteworthy change was also observed in the intraocular pressure (IOP) readings. The results indicated a decrease in the clinical signs of uveitis after administering the dexamethasone-loaded nanoparticles, accompanied by a reduction in pro-inflammatory cytokines. These findings suggest that dexamethasone-loaded nanoparticles may serve as a potential treatment for uveitis.