Akademik Veri Yönetim Sistemi
Journal de Pharmacie de Belgique, cilt.53, sa.3, ss.232, 1998 (SCI-Expanded)
The diphenylbutylpiperidines can be considered as a modification of the fluorobutyrophenones. Pimozide, a member of this class, is a antipsychotic drug that is used primarily for the treatment of Tourettes syndrome. In this work, an electroanalytical study of the oxidation of pimozide at the glassy carbon and carbon paste electrodes using different voltammetric techniques was carried out. The influence of pH, scan rate, concentration and presence of surfactant was carefully examined by linear scan and cyclic voltammetry. Using differential pulse voltammetry at a glassy carbon electrode, the drug yielded a well-defined voltammetric response in Britton-Robinson buffer pH 2.1, with 10 % methanol at about +1.1 V (vs Ag/AgCl) . The results allowed a method to be developed for the determination of pimozide in the ranges 8×10-7 - 1×10-4 M with a slope of 5.32 mA / 10-4 M . With the knowledge of the oxidation of pimozide as a function of pH, a reversed-phase HPLC method with electrochemical detection was also described using a mobile phase of methanol and phosphate buffer pH 4.5 (85:15) and a working electrode potential at + 0.75 V (vs Ag/AgCl ). The calibration curve was linear, ranging between 5.4×10-10- 1.1×10-4 M with a detection limit of 2.7 × 10-10 M. Both procedures were applied to the determination of pimozide in tablets.