Electrochemical oxidation pathway of the anti-cancer agent dasatinib using disposable pencil graphite electrode and its adsorptive stripping voltammetric determination in biological samples
Journal of the Turkish Chemical Society, Section A: Chemistry, cilt.5, sa.2, ss.381-392, 2018 (Scopus, TRDizin)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 5 Sayı: 2
- Basım Tarihi: 2018
- Doi Numarası: 10.18596/jotcsa.345238
- Dergi Adı: Journal of the Turkish Chemical Society, Section A: Chemistry
- Derginin Tarandığı İndeksler: Scopus, TR DİZİN (ULAKBİM)
- Sayfa Sayıları: ss.381-392
- Anahtar Kelimeler: Dasatinib, Pencil graphite electrode, Urine, Voltammetry
- Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
- Ankara Üniversitesi Adresli: Evet
Özet
© 2018, Turkish Chemical Society. All rights reserved.The present study describes the use of pencil graphite electrode (PGE) so as to investigate the electro-oxidation mechanism and voltammetric stripping determination of dasatinib (DST) in Britton-Robinson buffer solution (BR). Relating to cyclic voltammetric studies, an irreversible oxidation signal was obtained at about 1.0 V. The oxidation electrode process is adsorption-controlled and pH-dependent. For quantitative determination of DST, square wave adsorptive stripping voltammetry (AdsSWV) was employed in BR of pH 3.0. The oxidation signal varies linearly with the DST concentration in the range of 0.0092 – 1.0 µM. Detection and quantification (LOD and LOQ) values are founded as 0.0028 µM and 0.0092 µM, respectively. The developed AdsSWV method based on disposible and cheap PGE was applied successfully to the real human urine samples and the recovery results are given in the range of 97.94% to 100.82%.