Atıf İçin Kopyala
Toydemir P., ELHAN A. H., Tukun A., Toydemir R., Gurler A., Tuzuner A., ...Daha Fazla
JOURNAL OF RHEUMATOLOGY, cilt.27, sa.12, ss.2849-2854, 2000 (SCI-Expanded)
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Yayın Türü:
Makale / Tam Makale
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Cilt numarası:
27
Sayı:
12
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Basım Tarihi:
2000
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Dergi Adı:
JOURNAL OF RHEUMATOLOGY
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Derginin Tarandığı İndeksler:
Science Citation Index Expanded (SCI-EXPANDED), Scopus
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Sayfa Sayıları:
ss.2849-2854
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Anahtar Kelimeler:
Behcet's disease, deep venous thrombosis, MTHFR C677T mutation, prothrombin G20210A mutation, factor V Leiden mutation, ACTIVATED PROTEIN-C, CORONARY-ARTERY DISEASE, ANTIENDOTHELIAL CELL ANTIBODIES, PLASMA TOTAL HOMOCYSTEINE, NEURAL-TUBE DEFECTS, RISK FACTOR, LEIDEN MUTATION, VASCULAR-DISEASE, VEIN THROMBOSIS, COMMON MUTATION
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Ankara Üniversitesi Adresli:
Evet
Özet
Objective, Behcet's disease (BD) is a multisystemic disease of unknown etiology, characterized by aphthous ulcerations and uveitis, that is common in the Turkish population. Venous involvement is observed in 25% of the cases, While superficial thrombophlebitis is the most common Finding, deep venous thrombosis (DVT) follows it. Hyperactivity in the coagulation pathway, hypoactive anticoagulation mechanisms, or faulty fibrinolysis generate a tendency for thrombogenesis. Mutations of the genes involved in these pathways may cause predisposition to thrombosis.