Effects of factor V gene G1691A, methylenetetrahydrofolate reductase gene C677T, and prothrombin gene G20210A mutations on deep venous thrombogenesis in Behcet's disease
JOURNAL OF RHEUMATOLOGY, cilt.27, sa.12, ss.2849-2854, 2000 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 27 Sayı: 12
- Basım Tarihi: 2000
- Dergi Adı: JOURNAL OF RHEUMATOLOGY
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.2849-2854
- Anahtar Kelimeler: Behcet's disease, deep venous thrombosis, MTHFR C677T mutation, prothrombin G20210A mutation, factor V Leiden mutation, ACTIVATED PROTEIN-C, CORONARY-ARTERY DISEASE, ANTIENDOTHELIAL CELL ANTIBODIES, PLASMA TOTAL HOMOCYSTEINE, NEURAL-TUBE DEFECTS, RISK FACTOR, LEIDEN MUTATION, VASCULAR-DISEASE, VEIN THROMBOSIS, COMMON MUTATION
- Ankara Üniversitesi Adresli: Evet
Özet
Objective, Behcet's disease (BD) is a multisystemic disease of unknown etiology, characterized by aphthous ulcerations and uveitis, that is common in the Turkish population. Venous involvement is observed in 25% of the cases, While superficial thrombophlebitis is the most common Finding, deep venous thrombosis (DVT) follows it. Hyperactivity in the coagulation pathway, hypoactive anticoagulation mechanisms, or faulty fibrinolysis generate a tendency for thrombogenesis. Mutations of the genes involved in these pathways may cause predisposition to thrombosis.