Effects of factor V gene G1691A, methylenetetrahydrofolate reductase gene C677T, and prothrombin gene G20210A mutations on deep venous thrombogenesis in Behcet's disease

Toydemir P., ELHAN A. H., Tukun A., Toydemir R., Gurler A., Tuzuner A., ...More

JOURNAL OF RHEUMATOLOGY, vol.27, no.12, pp.2849-2854, 2000 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 27 Issue: 12
  • Publication Date: 2000
  • Journal Name: JOURNAL OF RHEUMATOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.2849-2854
  • Keywords: Behcet's disease, deep venous thrombosis, MTHFR C677T mutation, prothrombin G20210A mutation, factor V Leiden mutation, ACTIVATED PROTEIN-C, CORONARY-ARTERY DISEASE, ANTIENDOTHELIAL CELL ANTIBODIES, PLASMA TOTAL HOMOCYSTEINE, NEURAL-TUBE DEFECTS, RISK FACTOR, LEIDEN MUTATION, VASCULAR-DISEASE, VEIN THROMBOSIS, COMMON MUTATION
  • Ankara University Affiliated: Yes

Abstract

Objective, Behcet's disease (BD) is a multisystemic disease of unknown etiology, characterized by aphthous ulcerations and uveitis, that is common in the Turkish population. Venous involvement is observed in 25% of the cases, While superficial thrombophlebitis is the most common Finding, deep venous thrombosis (DVT) follows it. Hyperactivity in the coagulation pathway, hypoactive anticoagulation mechanisms, or faulty fibrinolysis generate a tendency for thrombogenesis. Mutations of the genes involved in these pathways may cause predisposition to thrombosis.