Effect of Riluzole on Spinal Cord Regeneration with Hemisection Method Before Injury

ÇAĞLAR, YUSUF; Demirel, Altan; DOĞAN, İHSAN; Huseynov, Ramis; EROĞLU, ÜMİT; ÖZGÜRAL, ONUR; CANSIZ ERSÖZ, CEVRİYE; Bahadir, Burak; Kilinc, Mustafa; Al-Beyati, EYÜP

doi:10.1016/j.wneu.2018.02.171

Effect of Riluzole on Spinal Cord Regeneration with Hemisection Method Before Injury

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ÇAĞLAR Y. Ş., Demirel A., DOĞAN İ., Huseynov R., EROĞLU Ü., ÖZGÜRAL O., ...More

WORLD NEUROSURGERY, vol.114, 2018 (SCI-Expanded)

Publication Type: Article / Article
Volume: 114
Publication Date: 2018
Doi Number: 10.1016/j.wneu.2018.02.171
Journal Name: WORLD NEUROSURGERY
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Keywords: Neuroprotection, Neuroregeneration, Riluzole, Spinal cord injury, SODIUM-CHANNEL BLOCKERS, VENTRAL ROOT AVULSION, FUNCTIONAL RECOVERY, ISCHEMIA
Ankara University Affiliated: Yes

Abstract

OBJECTIVE: The pathophysiology of spinal cord injury (SCI) with the information obtained to date has not been elucidated fully. A safe drug or treatment protocol that results in cell regeneration for SCI remains unknown. Neuroprotective and neuroregenerative effects of riluzole, administered after a SCI, have been shown in experimental studies. This study aimed to investigate the effect of riluzole on neural regeneration in a rat SCI model.