Effect of Riluzole on Spinal Cord Regeneration with Hemisection Method Before Injury

ÇAĞLAR Y. Ş., Demirel A., DOĞAN İ., Huseynov R., EROĞLU Ü., ÖZGÜRAL O., ...Daha Fazla

WORLD NEUROSURGERY, cilt.114, 2018 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 114
  • Basım Tarihi: 2018
  • Doi Numarası: 10.1016/j.wneu.2018.02.171
  • Dergi Adı: WORLD NEUROSURGERY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Anahtar Kelimeler: Neuroprotection, Neuroregeneration, Riluzole, Spinal cord injury, SODIUM-CHANNEL BLOCKERS, VENTRAL ROOT AVULSION, FUNCTIONAL RECOVERY, ISCHEMIA
  • Ankara Üniversitesi Adresli: Evet

Özet

OBJECTIVE: The pathophysiology of spinal cord injury (SCI) with the information obtained to date has not been elucidated fully. A safe drug or treatment protocol that results in cell regeneration for SCI remains unknown. Neuroprotective and neuroregenerative effects of riluzole, administered after a SCI, have been shown in experimental studies. This study aimed to investigate the effect of riluzole on neural regeneration in a rat SCI model.