Could lysosomal acid lipase enzyme activity be used for clinical follow-up in cryptogenic cirrhosis?

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KÖSE E., Cagatay E., Yaras T., Kisa P. T., Guler S., Gulten Z. A., ...Daha Fazla

TURKISH JOURNAL OF MEDICAL SCIENCES, cilt.52, sa.4, ss.1075-1084, 2022 (SCI-Expanded) identifier identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 52 Sayı: 4
  • Basım Tarihi: 2022
  • Doi Numarası: 10.55730/1300-0144.5410
  • Dergi Adı: TURKISH JOURNAL OF MEDICAL SCIENCES
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, CAB Abstracts, EMBASE, MEDLINE, Veterinary Science Database, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.1075-1084
  • Anahtar Kelimeler: Cholesterol ester storage disease, cryptogenic cirrhosis, lysosomal acid lipase deficiency, LIPA gene, ESTER STORAGE DISEASE
  • Ankara Üniversitesi Adresli: Evet

Özet

Background/aim: Cholesterol ester storage disease (CESD) is one of the rare causes that should be kept in mind in the etiology of cirrhosis. Recent studies detected that significantly reduced lysosomal acid lipase deficiency enzyme (LAL) in patients with cryptogenic cirrhosis (CC). Moreover, studies have evaluated that LAL activity is as effective as scoring systems in assessing the severity of cirrhosis.