Mucocutaneous Manifestations of Behcet's Disease

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BOYVAT A.

TURKDERM-TURKISH ARCHIVES OF DERMATOLOGY AND VENEROLOGY, vol.43, pp.42-47, 2009 (SCI-Expanded)

• Publication Type: Article / Article
• Volume: 43
• Publication Date: 2009
• Journal Name: TURKDERM-TURKISH ARCHIVES OF DERMATOLOGY AND VENEROLOGY
• Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Emerging Sources Citation Index (ESCI), Scopus, TR DİZİN (ULAKBİM)
• Page Numbers: pp.42-47
• Keywords: Behcet's disease, mucocutaneous, oral aphthous ulceration, genital ulcer, erythema nodosum, papulopustular lesion, thrombophlebitis, pathergy, DERMATOSIS SWEETS-SYNDROME, NODOSUM-LIKE LESIONS, PYODERMA-GANGRENOSUM, PAPULOPUSTULAR LESIONS, PATHERGY REACTION, HISTOPATHOLOGIC FEATURES, FOLLOW-UP, SKIN, APHTHOSIS, TURKISH
• Ankara University Affiliated: Yes

Abstract

Recurrent oral aphthous ulcerations, genital ulcerations and cutaneous manifestations including erythema nodosum like lesions, superficial thrombophlebitis and papulopustular lesions are the most common manifestations of Behcet's disease. The pathergy reaction reflects skin hypersensitivity to travma in Behcet's disease. Pathergy test which is characterized by the formation of a sterile pustule 24-48 h after intradermal needle prick has a high diagnostic value especially in Middle East and Mediterrenian countries. Due to their high sensitivity, mucocutaneous lesions and pathergy test constitude four out of the five criteria in the International Behcet's Disease study group classification criteria. Behcet's disease has a wide clinical spectrum and since there are no specific diagnostic laboratory tests, diagnosis depends on clinical acumen of the physician. In the majority of patients with systemic findings, mucocutaneous lesions precede the onset of systemic involvement and therefore prompt recognition of mucocutaneous manifestations is of utmost importance in the early diagnosis and the outcome of the disease. (Turkderm 2009; 43 Suppl 2: 42-7)