Sorafenib and lithium chloride combination treatment shows promising synergistic effects in human glioblastoma multiforme cells in vitro but midkine is not implicated

Sabanci, Pulat; ERGÜVEN, MİNE; YAZIHAN, NURAY; Aktas, Esin; Aras, Yavuz; Civelek, Erdinc; Aydoseli, Aydin; Imer, Murat; Gurtekin, Mehmet; Bilir, Ayhan

doi:10.1179/1743132813y.0000000283

Sorafenib and lithium chloride combination treatment shows promising synergistic effects in human glioblastoma multiforme cells in vitro but midkine is not implicated

Sabanci P. A., ERGÜVEN M., YAZIHAN N., Aktas E., Aras Y., Civelek E., ...Daha Fazla

NEUROLOGICAL RESEARCH, cilt.36, sa.3, ss.189-197, 2014 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 36 Sayı: 3
Basım Tarihi: 2014
Doi Numarası: 10.1179/1743132813y.0000000283
Dergi Adı: NEUROLOGICAL RESEARCH
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.189-197
Anahtar Kelimeler: Combination chemotherapy, Glioblastoma, Lithium chloride, Midkine, Sorafenib, GLYCOGEN-SYNTHASE KINASE-3, HEPATOCELLULAR-CARCINOMA, IMATINIB MESYLATE, BREAST-CANCER, GLIOMA-CELLS, INHIBITION, RESISTANCE, APOPTOSIS, PATHWAYS, LINES
Ankara Üniversitesi Adresli: Evet

Özet

Objectives: The objectives of this study were to test the effects of the new combination treatment modality, sorafenib (SOR) and lithium chloride (LiCl) and to assess whether midkine (MK) protein has a role in any potential effects.