Layer by layer assembly of core-corona structured solid lipid nanoparticles with beta-cyclodextrin polymers

AMASYA G., BAKAR ATEŞ F., Wintgens V., Amiel C.

INTERNATIONAL JOURNAL OF PHARMACEUTICS, cilt.592, 2021 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 592
  • Basım Tarihi: 2021
  • Doi Numarası: 10.1016/j.ijpharm.2020.119994
  • Dergi Adı: INTERNATIONAL JOURNAL OF PHARMACEUTICS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Aquatic Science & Fisheries Abstracts (ASFA), BIOSIS, Biotechnology Research Abstracts, CAB Abstracts, Chemical Abstracts Core, EMBASE, International Pharmaceutical Abstracts, MEDLINE, Veterinary Science Database
  • Anahtar Kelimeler: Solid lipid nanoparticles (SLN), Layer by layer assembly, Oppositely charged beta-cyclodextrin polymers (poly-beta-CDs), Core-corona structure, Surface modified SLN, CONTROLLED DRUG-DELIVERY, VITRO RELEASE KINETICS, PLA NANOPARTICLES, SLN, CARRIERS, PACLITAXEL, STABILITY, DESIGN, NLC
  • Ankara Üniversitesi Adresli: Evet

Özet

This study aims to design and characterize the layer-by-layer assembly of core-corona nanoarchitecture for novel surface-modified solid lipid nanoparticles. Oppositely charged beta-cyclodextrin polymers were used to build corona structure onto lipid core, and the particle size, polydispersity index, and zeta potential of SLN with polymer layers were evaluated. Morphology of surface-modified SLN was identified using TEM. The effect of polymer coating on drug release pattern was investigated by in-vitro release studies. The biocompatibility of the novel SLN systems was assessed on various healty cell lines using in vitro cytotoxicity assay.