Impact of PD-1 and PD-L1 expression on treatment outcomes in newly diagnosed acute myeloid leukemia patients

Calis U., Aydogan M., CENGİZ SEVAL G., DALVA K., TOPRAK S. K.

Leukemia Research Reports, cilt.23, 2025 (Scopus) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 23
  • Basım Tarihi: 2025
  • Doi Numarası: 10.1016/j.lrr.2025.100514
  • Dergi Adı: Leukemia Research Reports
  • Derginin Tarandığı İndeksler: Scopus, Directory of Open Access Journals
  • Anahtar Kelimeler: Acute myeloid Leukemia, Aml, Flow cytometry, PD-1, PD-L1
  • Ankara Üniversitesi Adresli: Evet

Özet

High expression of immune checkpoint markers may leukemic cells to evade the immune system in AML. This study aimed to investigate the relationship between PD-1/PD-L1 expression and treatment outcomes in AML patients. The study included 21 patients and 18 healthy volunteers. Non-responders exhibited significantly higher PD-1 expression (MFI) in CD3+ and CD4+ T cells. At the time of diagnosis, bone marrow samples from patients exhibited a significantly higher proportion of PD-1 expression in CD3+, CD4+, and CD8+ T lymphocytes than peripheral blood samples. The results revealed an association between PD-1/PD-L1 expression and clinical traits in newly diagnosed AML patients.