The role of metal coordination complexes in cytosolic cellular defense

Isgor B. S., Isgor Y. G., Ozalp-Yaman S.

PURE AND APPLIED CHEMISTRY, cilt.85, sa.2, ss.365-375, 2013 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 85 Sayı: 2
  • Basım Tarihi: 2013
  • Doi Numarası: 10.1351/pac-con-12-06-10
  • Dergi Adı: PURE AND APPLIED CHEMISTRY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.365-375
  • Anahtar Kelimeler: anticancer activity, antioxidant activity, bioactive molecules, biomolecular chemistry, biotechnology, bioinorganic chemistry, bioanalytical methods, drug resistance, enzyme inhibitors, glutathione metabolizing enzymes, protein tyrosine kinase, symmetrical metal complexes, GLUTATHIONE-S-TRANSFERASE, SUPEROXIDE-DISMUTASE, ELECTRONIC-STRUCTURE, PEROXIDASE ACTIVITY, PLATINUM, CATALASE, CISPLATIN, ENZYME, ACTIVATION, MECHANISMS
  • Ankara Üniversitesi Adresli: Hayır

Özet

The metal coordination complexes are known to induce cytotoxic effects on various cell lines and shown to have great potential for therapeutic interventions. Their main mechanism of action is through the mediation of enzyme activities in signaling pathways essential for cellular functioning. The overall cellular responses are dose-dependent and require high exposure levels and duration to overcome cellular defense against external toxicants. However, their effect through signal transduction components is limited due to the conferred drug resistance associated with glutathione transferase (GST)-mediated mechanisms. The GST family of enzymes is not only related to anticancer drug resistance, but also associated with cancer development where they may also contribute kinase signaling events including non-receptor protein tyrosine kinase (PTK)-related pathways. In the current study, we evaluated the effect of symmetrical and mononuclear complexes of Pd(II), Pt(II), and Ni(II) with organic ligands on cytosolic targets involved in glutathione utilization, anti oxidant defense, and kinase signaling by virtue of acellular in vitro analyses.