Potent Antifungal and Antistaphylococcal 2-Anilinobenzimidazoles

GÖKER A. H., Karaaslan C., Yildiz S.

ZEITSCHRIFT FUR NATURFORSCHUNG SECTION C-A JOURNAL OF BIOSCIENCES, cilt.67, sa.9-10, ss.486-494, 2012 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 67 Sayı: 9-10
  • Basım Tarihi: 2012
  • Doi Numarası: 10.1515/znc-2012-9-1007
  • Dergi Adı: ZEITSCHRIFT FUR NATURFORSCHUNG SECTION C-A JOURNAL OF BIOSCIENCES
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.486-494
  • Anahtar Kelimeler: Anilinobenzimidazoles, Antistaphylococcal Activity, Antifungal Activity, DERIVATIVES, ANTAGONISTS, AGENTS, ACIDS
  • Ankara Üniversitesi Adresli: Evet

Özet

A series of 21 anilinobenzimidazoles with a 2,4-difluorophenyl group were synthesized and their minimum inhibitory concentrations (MIC) determined by the tube dilution method. Most of the compounds exhibited excellent MIC values against Staphylococcus aureus and methicillin-resistant S. aureus (MRSA). Among them, compound 27 having dibromo substitution at the 4- and 6-position of the benzimidazole ring showed the best antifungal activity against Candida krusei with a MIC value of 3.12 mu g/mL that surpassed that of the reference drug fluconazole.