Do the Anti-Mullerian Hormone Levels of Adolescents with Polycystic Ovary Syndrome, Those Who Are at Risk for Developing Polycystic Ovary Syndrome, and Those Who Exhibit Isolated Oligomenorrhea Differ from Those of Adolescents with Normal Menstrual Cycles?

Savas-Erdeve S., Keskin M., Sagsak E., Cenesiz F., Cetinkaya S., AYCAN Z.

HORMONE RESEARCH IN PAEDIATRICS, cilt.85, sa.6, ss.406-411, 2016 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 85 Sayı: 6
  • Basım Tarihi: 2016
  • Doi Numarası: 10.1159/000446111
  • Dergi Adı: HORMONE RESEARCH IN PAEDIATRICS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.406-411
  • Anahtar Kelimeler: Anti-Mullerian hormone, Polycystic ovary syndrome, Oligomenorrhea, Normal menstrual cycle, BODY-MASS INDEX, ANTIMULLERIAN HORMONE, INHIBITING SUBSTANCE, ANTRAL FOLLICLE, DIAGNOSIS, WOMEN, GIRLS, AMH, DEFINITION, ULTRASOUND
  • Ankara Üniversitesi Adresli: Hayır

Özet

Background/Aims: We aimed to investigate whether the anti-Mullerian hormone (AMH) levels in adolescents with polycystic ovary syndrome (PCOS), PCOS risk, and isolated oligomenorrhea (OM) were different than in adolescents with a normal/regular menstrual cycle (NMC). Methods: The diagnosis of PCOS was based on the 2012 Amsterdam [European Society of Human Reproduction and Embryology/American Society for Reproductive Medicine (ESHRE/ASRM)] criteria. The PCOS group consisted of cases meeting 3 diagnostic criteria (n = 21), and the PCOS risk group was the 'at risk' group meeting 2 diagnostic criteria (n = 20). Cases with isolated OM that did not satisfy other PCOS diagnostic criteria made up the OM group (n = 21). Thirty adolescent girls with NMCs (21-45 days) were recruited in this study. Results: The AMH levels in the PCOS group were similar to those in the PCOS risk group but significantly higher than those in the OM and NMC groups. The AMH levels in the PCOS risk group were similar to those in the OM group and significantly higher than those in the NMC group. They were also significantly higher in the OM group compared to the NMC group. The specificity for PCOS and PCOS risk with a cutoff value of 7.25 ng/ml for AMH was 72.5% and the sensitivity was 58%. Conclusion: An AMH cutoff value of 7.25 ng/ml can be used for the diagnosis of PCOS in the adolescent period. (C) 2016 S. Karger AG, Basel