Serum interleukin-4 (IL-4) levels in patients with allergic rhinitis and changes after short-term immunotherapy

KINIKLI G., Tulek N., Bektas A., Turgay M., Tutkak H., DUMAN M., ...Daha Fazla

Turkish Journal of Medical Sciences, cilt.26, sa.4, ss.361-363, 1996 (SCI-Expanded) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 26 Sayı: 4
  • Basım Tarihi: 1996
  • Dergi Adı: Turkish Journal of Medical Sciences
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.361-363
  • Anahtar Kelimeler: allergic rhinitis, cytokines, immunotherapy, interleukin-4
  • Ankara Üniversitesi Adresli: Evet

Özet

IL-4 is a T-cell-derived cytokine that is required for the synthesis of IgE. In order to investigate the significance of IL-4 blood levels in measuring the diseases activity and the effectiveness of immunotherapy in the early stages, serum IL-4 levels were evaluated in patients with allergic rhinitis both at the outset of immunotherapy and six months into it. The study population consisted of 27 patients; 20 healthy nonatopic individuals served as a control. Serum IL-4 levels were measured with the ELISA Kit, after which we compared the results and correlated them with symptom scores. Although patients before immunotherapy showed slightly higher serum levels of IL-4 and these diminished during six months of immunotherapy, this wasn't statistically important. No correlation was found between IL-4 levels and symptom scores. Our results suggest that serum IL-4 levels aren't helpful in measuring the disease's activity or the effectiveness of immunotherapy in atopic patients.