Simultaneous Trace Electrochemical Determination of Xanthine Theophylline and Theobromine with a Novel Sensor Based on a Composite Including Metal Oxide Nanoparticle Multi-walled Carbon Nanotube and Nano-Na-montmorillonite Clay

Fitoz A., YAZAN Z., ÖNAL M.

ELECTROANALYSIS, vol.33, no.10, pp.2226-2234, 2021 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 33 Issue: 10
  • Publication Date: 2021
  • Doi Number: 10.1002/elan.202100196
  • Journal Name: ELECTROANALYSIS
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Aerospace Database, Applied Science & Technology Source, BIOSIS, Chemical Abstracts Core, Chimica, Communication Abstracts, Metadex, Civil Engineering Abstracts
  • Page Numbers: pp.2226-2234
  • Keywords: Electrochemical sensor, Nano-participles, Xanthine, Theophylline, Theobromine, SIMULTANEOUS VOLTAMMETRIC DETERMINATION, ASCORBIC-ACID, FOOD SAMPLES, ELECTRODE, GRAPHITE, CAFFEINE, ELECTROOXIDATION, PRODUCTS
  • Ankara University Affiliated: Yes

Abstract

We report the simultaneous determination of purine molecules with biological significance on pencil graphite electrode (PGE) modified with a composite solution including NiO nanoparticles, multi-walled carbon nanotube (MWCNT), and natural nano-Na-montmorillonite clay (NNaM) using DPV technique. The novel sensor, NiO/MWCNT/NNaM/PGE, achieved simultaneous determination of xanthine, theophylline, and theobromine at the detection limits 0.077 mu M, 0.361 mu M, and 0.458 mu M with the linear working ranges 0.5-150 mu M, 5-200 mu M, and 5-250 mu M in Britton-Robinson buffer at pH 2.0, respectively. The sensor revealed excellent performance for the simultaneous determination of XT, TP, and TB in three real-world samples.