The effects of chronomodulated therapy with 5-fluorouracil (5-Fu) and folinic acid (Fa) on the toxicity and quality of life in patients with advanced gastric cancer
BIOLOGICAL RHYTHM RESEARCH, vol.35, no.4-5, pp.259-268, 2004 (SCI-Expanded, Scopus)
- Publication Type: Article / Article
- Volume: 35 Issue: 4-5
- Publication Date: 2004
- Doi Number: 10.1080/09291010400011324a
- Journal Name: BIOLOGICAL RHYTHM RESEARCH
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Page Numbers: pp.259-268
- Keywords: chronotherapy, fluorouracil, gastric cancer, quality of life, HUMAN BONE-MARROW, COLORECTAL-CANCER, CIRCADIAN VARIATION, DNA-SYNTHESIS, RHYTHMS, PROLIFERATION, INFUSION, CHEMOTHERAPY, FLOXURIDINE, METASTASES
- Ankara University Affiliated: Yes
Abstract
This study was designed to assess the tolerability of chronomodulated infusion chemotherapy, individualized by the rhythm of peripheral blood cells. Twenty patients with metastatic gastric cancer were randomized to chronotherapy or day-time arms of 5-fluorouracil (FU) (600 mg/m(2), 8 h inf.dl-5) and folinic acid (FA) (20 mg/m(2), iv, dl-5) in the first cycle and crossed-over to the other arm in the following cycles. Ten of 18 evaluable patients were assigned to chronotherapy arm and eight to day-time in the first cycle. Although there was no significant difference between two arms on enrollment, chronotherapy arm yielded an improvement of 45% of QLQ-C30 scores (p = 0.021) and the day-time arm had 11% improvement (p = 0.575). After the crossing-over, chronotherapy arm, again, had a significant improvement in QLQ-C30 scores, compared to the day-time arm (14% vs. -18%, p = 0.001, respectively). Mucositis/diarrhea was significantly higher in the day-time arm compared to chronotherapy arm (p = 0.015). In conclusion, chronomodulated infusion of 5-FU might improve the quality of life.