The effects of chronomodulated therapy with 5-fluorouracil (5-Fu) and folinic acid (Fa) on the toxicity and quality of life in patients with advanced gastric cancer

Yalcin B., AKBULUT H., Buyukcelik A., Sencan O., Demirkazik A., Onur H., ...Daha Fazla

BIOLOGICAL RHYTHM RESEARCH, cilt.35, sa.4-5, ss.259-268, 2004 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 35 Sayı: 4-5
  • Basım Tarihi: 2004
  • Doi Numarası: 10.1080/09291010400011324a
  • Dergi Adı: BIOLOGICAL RHYTHM RESEARCH
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.259-268
  • Anahtar Kelimeler: chronotherapy, fluorouracil, gastric cancer, quality of life, HUMAN BONE-MARROW, COLORECTAL-CANCER, CIRCADIAN VARIATION, DNA-SYNTHESIS, RHYTHMS, PROLIFERATION, INFUSION, CHEMOTHERAPY, FLOXURIDINE, METASTASES
  • Ankara Üniversitesi Adresli: Evet

Özet

This study was designed to assess the tolerability of chronomodulated infusion chemotherapy, individualized by the rhythm of peripheral blood cells. Twenty patients with metastatic gastric cancer were randomized to chronotherapy or day-time arms of 5-fluorouracil (FU) (600 mg/m(2), 8 h inf.dl-5) and folinic acid (FA) (20 mg/m(2), iv, dl-5) in the first cycle and crossed-over to the other arm in the following cycles. Ten of 18 evaluable patients were assigned to chronotherapy arm and eight to day-time in the first cycle. Although there was no significant difference between two arms on enrollment, chronotherapy arm yielded an improvement of 45% of QLQ-C30 scores (p = 0.021) and the day-time arm had 11% improvement (p = 0.575). After the crossing-over, chronotherapy arm, again, had a significant improvement in QLQ-C30 scores, compared to the day-time arm (14% vs. -18%, p = 0.001, respectively). Mucositis/diarrhea was significantly higher in the day-time arm compared to chronotherapy arm (p = 0.015). In conclusion, chronomodulated infusion of 5-FU might improve the quality of life.