Combination of Electrochemical, Spectrometric and Other Analytical Techniques for High Throughput Screening of Pharmaceutically Active Compounds

SÜZEN S., ÖZKAN S. A.

COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING, cilt.13, sa.7, ss.658-664, 2010 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 13 Sayı: 7
  • Basım Tarihi: 2010
  • Doi Numarası: 10.2174/1386207311004070658
  • Dergi Adı: COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.658-664
  • Anahtar Kelimeler: Electrochemistry, voltammetry, mass spectrometry, HPLC, chemiluminescence, TANDEM MASS-SPECTROMETRY, IN-VITRO, DOSAGE FORMS, HUMAN SERUM, DRUG-METABOLISM, COUPLED ONLINE, HPLC-EC, IDENTIFICATION, OXIDATION, QUANTIFICATION
  • Ankara Üniversitesi Adresli: Evet

Özet

Recently, the use of electrochemistry and combination of this method with spectroscopic and other analytical techniques are becoming one of the important approaches in drug discovery and research as well as quality control, drug stability, determination of physiological activity, and measurement of neurotransmitters. Many fundamental physiological processes depend on oxido-reduction reactions in the body. Therefore, it may be possible to find connections between electrochemical and biochemical reactions concerning electron transfer pathways. Applications of electrochemical techniques to redox-active drug development and studies are one of the recent interests in drug discovery. In this review, the latest developments related to the use of electrochemical techniques in drug research will be surveyed in order to evaluate possible combinations of spectrometric methods with electrochemical techniques.