Novel Drug Delivery System for Dermal Uptake of Etofenamate: Semisolid SLN Dispersion

BADILLI F. U., ŞENGEL TÜRK C. T., AMASYA G., Tarimci N.

CURRENT DRUG DELIVERY, cilt.14, sa.3, ss.386-393, 2017 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 14 Sayı: 3
  • Basım Tarihi: 2017
  • Doi Numarası: 10.2174/1567201813666160808110245
  • Dergi Adı: CURRENT DRUG DELIVERY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.386-393
  • Anahtar Kelimeler: Dermal uptake, etofenamate, occlusive effect, semisolid SLN dispersion, texture profile analysis, skin penetration, SOLID LIPID NANOPARTICLES, IN-VITRO, LECITHIN/CHITOSAN NANOPARTICLES, MUCOADHESIVE PROPERTIES, TOPICAL APPLICATION, SKIN, BIOADHESIVE, RELEASE, FORMULATION, CARRIER
  • Ankara Üniversitesi Adresli: Evet

Özet

Background: Semisolid SLNs are novel strategy for dermal drug administration instead of incorporating the SLN dispersions into conventional semisolids. Etofenamate loaded semisolid SLNs were successfully prepared and in vitro characterization of formulations were performed in our previous study. The present study is an attempt to evaluate the dermal behavior of the semisolid SLNs selected on the basis of previous research and investigate the properties in terms of the convenience for topical applications.