Activities of cytoplasmic and mitochondrial superoxide dismutase isoenzymes in cancerous human renal tissues

Kaçmaz M., Biri H., Kavutcu M., ÖZTÜRK H. S., DURAK İ.

Cancer Research, Therapy and Control, cilt.10, sa.1-2, ss.25-29, 1999 (SCI-Expanded) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 10 Sayı: 1-2
  • Basım Tarihi: 1999
  • Dergi Adı: Cancer Research, Therapy and Control
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.25-29
  • Anahtar Kelimeler: Renal cancer, Superoxide dismutase isoenzymes
  • Ankara Üniversitesi Adresli: Evet

Özet

Activities of cytoplasmic (Cu,Zn-SOD) and mitochondrial (Mn-SOD) Superoxide dismutase isoenzymes were measured in cancerous and non-cancerous human renal tissues from same patients. Cu.Zn-SOD activity was found lower in cancerous tissues compared with those of non-cancerous ones. However, no difference was found between Mn-SOD activities of the tissues. We also observed no differences between SOD activities of the tissues with stage I-II and with stage I11-1V renal cancer. Results suggest that enzymatic free radical defense mechanism is reduced in the cancerous human renal tissues due to depressed Cu.Zn-SOD activity and cancerous renal tissues may be under oxidant stress. © 1999 OPA (Oversells Publishers Association) N.V. Published by license under the Harwood Academic Publishers imprint. part of the Gordon and Breach Publishing Group.