Activities of cytoplasmic and mitochondrial superoxide dismutase isoenzymes in cancerous human renal tissues
Cancer Research, Therapy and Control, cilt.10, sa.1-2, ss.25-29, 1999 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 10 Sayı: 1-2
- Basım Tarihi: 1999
- Dergi Adı: Cancer Research, Therapy and Control
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.25-29
- Anahtar Kelimeler: Renal cancer, Superoxide dismutase isoenzymes
- Ankara Üniversitesi Adresli: Evet
Özet
Activities of cytoplasmic (Cu,Zn-SOD) and mitochondrial (Mn-SOD) Superoxide dismutase isoenzymes were measured in cancerous and non-cancerous human renal tissues from same patients. Cu.Zn-SOD activity was found lower in cancerous tissues compared with those of non-cancerous ones. However, no difference was found between Mn-SOD activities of the tissues. We also observed no differences between SOD activities of the tissues with stage I-II and with stage I11-1V renal cancer. Results suggest that enzymatic free radical defense mechanism is reduced in the cancerous human renal tissues due to depressed Cu.Zn-SOD activity and cancerous renal tissues may be under oxidant stress. © 1999 OPA (Oversells Publishers Association) N.V. Published by license under the Harwood Academic Publishers imprint. part of the Gordon and Breach Publishing Group.