An Investigation of the Effects of Curcumin on the Changes in the Central Nervous System of Rats Exposed to Aroclor 1254 in the Prenatal Period

ALÇIĞIR M. E., DOĞAN H. O., YURDAKÖK DİKMEN B., Dogan K., Vural S., YILMAZ F. M., ...Daha Fazla

CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS, cilt.17, sa.2, ss.132-143, 2018 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 17 Sayı: 2
  • Basım Tarihi: 2018
  • Doi Numarası: 10.2174/1871527317666180315170146
  • Dergi Adı: CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.132-143
  • Anahtar Kelimeler: Aroclor 1254, biochemistry, curcumin, immunohistochemistry, pathomorphology, rat pups, NEURON-SPECIFIC ENOLASE, INDUCED OXIDATIVE STRESS, MYELIN BASIC-PROTEIN, POLYCHLORINATED-BIPHENYLS PCBS, CEREBELLAR GRANULE CELLS, PROTECTIVE ROLE, DEVELOPMENTAL EXPOSURE, CEREBROSPINAL-FLUID, ALZHEIMERS-DISEASE, CORTICAL-NEURONS
  • Ankara Üniversitesi Adresli: Evet

Özet

Background & Objective: Aroclor 1254 is a widespread toxic compound of Polychlorinated Biphenyls (PCBs), which can create significant nervous problems. No remedies have been found to date. The aim of this study was to reveal the damage that occurs in the central nervous system of rat pups exposed to Aroclor 1254 in the prenatal period and to show the inhibiting effect of curcumin, which is a strong anti-oxidant and neuroprotective substance.