Endothelial nitric oxide synthase gene intron 4 polymorphism predicts new onset diabetes mellitus after transplantation in kidney allograft recipients treated with cyclosporin A

Ergun I., KEVEN K., ŞENGÜL Ş., KARABULUT H. G., Kurultak I., Soypacaci Z., ...Daha Fazla

INTERNATIONAL UROLOGY AND NEPHROLOGY, cilt.43, sa.2, ss.543-548, 2011 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 43 Sayı: 2
  • Basım Tarihi: 2011
  • Doi Numarası: 10.1007/s11255-010-9786-8
  • Dergi Adı: INTERNATIONAL UROLOGY AND NEPHROLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.543-548
  • Anahtar Kelimeler: Diabetes mellitus, Endothelial nitric oxide synthase gene, Hepatitis c virus, Intron 4, Nitric oxide, Notad, Ptdm, Renal transplantation, INSULIN, ASSOCIATION, MICE
  • Ankara Üniversitesi Adresli: Evet

Özet

Nitric oxide (NO), synthesized from ls-arginine by the enzyme endothelial nitric oxide synthase (eNOS), is a potent vasodilator and has been implicated in mediating insulin-induced uptake and metabolism of glucose in skeletal muscle. Polymorphisms of the eNOS gene have been associated with altered eNOS activity and NO levels. Although several factors have been demonstrated for new onset diabetes mellitus after transplantation (NODAT), determining a genetic susceptibility for all patients requires further study. In our study, we evaluated the relationship between eNOS gene intron 4 polymorphism and NODAT in kidney allograft recipients.