The role of dehydroalanines in enzyme and peptide chemistry


SÜZEN S.

Ankara Universitesi Eczacilik Fakultesi Dergisi, vol.28, no.2, pp.129-141, 1999 (Scopus) identifier

  • Publication Type: Article / Article
  • Volume: 28 Issue: 2
  • Publication Date: 1999
  • Journal Name: Ankara Universitesi Eczacilik Fakultesi Dergisi
  • Journal Indexes: Scopus
  • Page Numbers: pp.129-141
  • Keywords: Antioxidant, Dehydration of serine, Dehydroalanine, Lantibiotic
  • Ankara University Affiliated: Yes

Abstract

α,β-Dehydroamino acids represent an important class of compound as they are key intermediates in amino acid and peptide synthesis and are constituents of a variety, of naturally occurring antibiotic and phytotoxic peptides including several fungal metabolites which posses antibiotic activity. They also play an important role at the active site of some enzymes and show free radical scavenging activity. It is believed that more detailed investigations are necessary to understand the importance of dehydroalanines.