Akademik Veri Yönetim Sistemi
ESMO 2025, Berlin, Almanya, 17 - 21 Ekim 2025, cilt.36, ss.1656-1657, (Özet Bildiri)
Background
Chemotherapy-induced peripheral neuropathy (CIPN) is a common side effect associated with the use of neurotoxic chemotherapeutics such as taxanes and platinum-based agents, which reduces patients' quality of life. Currently, there is no standardized method to prevent CIPN. Therefore, nonpharmacologic, safe and easily applicable interventions are important. Cold applications are thought to reduce the effect of chemotherapeutics on peripheral nerves by vasoconstriction in the extremities. This method, which is among nursing practices, may be an important tool in the management of peripheral neuropathy.Methods
This study aims to analyze the current literature evaluating the effectiveness of cold application as a nursing practice in the prevention of CIPN. Studies with high level of evidence (randomized controlled trials, systematic reviews and meta-analyses, and guidelines) on cold application in the management of chemotherapy-induced peripheral neuropathy in recent years were reviewed.Results
In most of the studies reviewed, cold application significantly reduced the incidence of chemotherapy-induced peripheral neuropathy. Peripheral neuropathy rates were significantly lower in groups using cold gloves, socks and hilotherapy. Especially in paclitaxel and oxaliplatin treatments, cold application was found to be effective on peripheral neuropathy in both subjective and objective measurements. However, some studies found no significant difference in overall neuropathy scores. However, improvement in specific symptoms (tingling, grip difficulty) and improvement in quality of life were found. Overall, cold application was considered a safe, tolerable and promising intervention.Conclusions
Cold application is an effective, low-cost intervention that can be integrated into nursing practices for the prevention of CIPN. However, the diversity of application methods and evaluation tools makes it difficult to establish an effective treatment protocol. Therefore, it is necessary to clarify the efficacy and safety through well-designed studies with larger samples. Nurses should take an active role in symptom management of patients by following such evidence-based practices.