N-acetylation phenotyping with sulphadimidine in a Turkish population

Bozkurt A., BAŞCI AKDUMAN N. E., Kalan S., TUNCER M., Kayaalp S.

European Journal of Clinical Pharmacology, vol.38, no.1, pp.53-56, 1990 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 38 Issue: 1
  • Publication Date: 1990
  • Doi Number: 10.1007/bf00314803
  • Journal Name: European Journal of Clinical Pharmacology
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.53-56
  • Keywords: Acetylation phenotype, Sulphadimidine, Turkish Population
  • Ankara University Affiliated: No

Abstract

The distribution of acetylator phenotypes was studied in 244 unrelated Turkish subjects. Sulphadimidine and its acetylated metabolite were measured in 6 h plasma and 0-6 h urine samples after an oral dose of 10 mg/kg. Subjects with 37.5% or less acetylsulphadimidine in plasma were regarded as slow acetylators and the others as rapid acetylators. The mean plasma concentration of acetylsulphadimidine was about 2.5-times lower in slow acetylators. Urinary excretion of total sulphadimidine (free + acetylated) was also significantly lower in slow acetylators compared to rapid acetylators. The frequency of slow acetylators was 60.7% in the population (95% confidence interval 54.3% to 66.8%). Sulphadimidine acetylation showed no variation due to sex, age, body weight or pre-existing disease. © 1990 Springer-Verlag.